Russia said Wednesday attempts to resolve security issues relating to Ukraine without Moscow's participation were a "road to nowhere," and that much diplomatic work needs to be done before Vladimir Putin and Volodymyr Zelenskyy are ever in the same room.

KYIV, Ukraine (AP) — Russia launched a rare drone and missile attack on western Ukraine overnight, officials said Thursday, striking targets including an American-owned electronics plant and injecting further uncertainty into the U.S.-led efforts to end the three-year-old war.

Pentagon officials have been meeting European counterparts with a mission to create security guarantees for Ukraine, to help end the current war with Russia and to prevent a future one.

Russia struck an American business with cruise missiles overnight in one of the largest aerial attacks of the war so far, Ukraine has said.

Republican strategist Karl Rove on Thursday underscored the stakes of the Russia-Ukraine peace talks, saying failure to come to a resolution could be the downfall of President Trump’s presidency.

Russia’s foreign minister has cast fresh doubt on peace talks, questioning “the legitimacy” of Ukrainian president Volodymyr Zelensky to sign any future agreements after targetting a US factory in a large bombardment on Ukraine.

Vladimir Putin is demanding that Ukraine give up all of the eastern Donbas region, renounce ambitions to join NATO, remain neutral and keep Western troops out of the country, three sources familiar with top-level Kremlin thinking told Reuters.