Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Cancer cells are subjected to high mechanical pressure that leads to a rupture of the nuclear envelope when migrating through ...

For immune cells, the actin cytoskeleton is more than a structural scaffold. Immune cells can migrate to sites of infection or form precise, short-lived contacts with other cells, by constantly ...

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Huntington's disease is a rare genetic disorder and a representative neurodegenerative disease, characterized by loss of ...

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics ...

It forms networks of thin, flexible filaments that affect the shape, stiffness, and movement of cells. Studies have found that aging alters actin expression, disrupting the cytoskeleton’s functions, ...