It examines the impact of mTOR on podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells—each playing a crucial role in kidney function.

The PI3K-Akt-mTOR pathway regulates several biological functions and it is frequently deregulated in human cancer. In ovarian cancer amplification or mutation of PI3KCA or AKT2 oncogenes, which ...

It functions within the FOXP2-SRPX2/μPAR pathway and interacts ... potentially via inhibiting the PI3K/Akt/mTOR pathway.

The authors comprehensively elaborate on the diversity and complexity of ILs' roles in AKI pathogenesis. The review also describes how ILs coordinate ...

In the past decade, there has been a growing amount of evidence suggesting mTOR's role in sarcoidosis. In 2017, researchers showed that activation of mTOR in macrophages could cause progressive ...

The identification of genetic events leading to PI3K/mTOR dysregulation together with the remarkable activity of everolimus in one patient showcases the clinical relevance of this pathway, validates ...