SISSETON, S.D. (Dakota News Now) - A Sisseton grocery store is closing its doors in search of a bigger location in the area.

SIOUX FALLS, S.D. (Dakota News Now) - SiouxperCon is returning to Sioux Falls for its tenth year this September! The event ...

SIOUX FALLS, S.D. (Dakota News Now) - Avera Hospitals has received $1 million in funding for virtual patient care and ...

The Nov. 10 game featuring Iowa State vs. Mississippi State will be the 100th NCAA Division I game played on Heritage Court.

A Sioux Falls man was arrested on kidnapping charges on Monday after not allowing two female victims to leave his home.

SIOUX FALLS, S.D. (Dakota News Now) - The Sioux Falls LifeLight Festival is taking place on August 31. LifeLight CEO Josh ...

SIOUX FALLS, S.D. (Dakota News Now) - The Community Action for Veterans is hosting a conference and expo on September 22-23.

Updated: 14 hours ago Governor Rhoden and Co will be joined by five students from the University of South Dakota.

Governor Rhoden and Co will be joined by five students from the University of South Dakota as part of their participation in ...

WILLIAMSPORT, PA and SIOUX FALLS, SD (Dakota News Now) -The Sioux Falls Little League to a quick 1-0 lead over Connecticut in ...

Alex Post is starting from scratch in the pool and training for the Paralympics, with the help of his coach and the entire ...

As part of the treatment trial, Jay does chemotherapy every other week for six months. Access to clinical trials is offered ...